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Article

Acoziborole resistance associated mutations in trypanosome CPSF3

2025-11-27

Abstract excerpt

Acoziborole is a safe, single dose, oral therapy, for treatment of both early and late-stage sleeping sickness, a deadly disease caused by African trypanosomes. Other benzoxaboroles show efficacy against other trypanosomatids, apicomplexans, fungi, bacteria, and viruses. Acoziborole targets the trypanosome pre-mRNA processing endonuclease, cleavage and polyadenylation specificity factor 3 (CPSF3), and triggers CPS...

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Identifiers and source

Literature Corpus work
31b67504-021e-539f-b159-ed833084eff1
DOI
10.1101/2025.11.26.690711
Open publication

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Acoziborole resistance associated mutations in trypanosome CPSF3DOI 10.1101/2025.11.26.690711
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