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Article

Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids.

Nucleic acids research - 12 Aug 2022

Altmann Simone, Rico Eva, Carvalho Sandra, Ridgway Melanie, Trenaman Anna, Donnelly Hannah, Tinti Michele, Wyllie Susan, Horn David

Abstract excerpt

Trypanosomatids cause the neglected tropical diseases, sleeping sickness, Chagas disease and the leishmaniases. Studies on these lethal parasites would be further facilitated by new and improved genetic technologies. Scalable precision editing methods, for example, could be used to improve our understanding of potential mutations associated with drug resistance, a current priority given that several new...

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Identifiers

PMID: 35524555
DOI: 10.1093/nar/gkac319
PMCID: PMC9371896

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