Article
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Nature communications - 6 Mar 2017
Sonoiki Ebere, Ng Caroline L, Lee Marcus C S, Guo Denghui, Zhang Yong-Kang, Zhou Yasheen, Alley M R K, Ahyong Vida, Sanz Laura M, Lafuente-Monasterio Maria Jose, Dong Chen, Schupp Patrick G, Gut Jiri, Legac Jenny, Cooper Roland A, Gamo Francisco-Javier, DeRisi Joseph, Freund Yvonne R, Fidock David A, Rosenthal Philip J
Abstract excerpt
Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium falciparum laboratory-adapted strains (mean IC50 32 nM), Ugandan field isolates (mean ex vivo IC50 64 nM), and murine P. berghei and P. falciparum infections (day 4 ED90 0.34 and 0.57 mg kg-1, respectively). Multiple P. falciparum lines selected in vitro for...
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