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Article

Acoziborole resistance associated mutations in Trypanosoma brucei CPSF3.

PLoS pathogens - 1 Mar 2026

Ridgway Melanie, Novotná Markéta, Mendoza-Martinez Cesar, Tinti Michele, Altmann Simone, Sloan Graeme, Horn David

Abstract excerpt

Acoziborole is a safe, single dose, oral therapy, for treatment of both early and late-stage sleeping sickness, a deadly disease caused by African trypanosomes. Other benzoxaboroles show efficacy against other trypanosomatids, apicomplexans, fungi, bacteria, and viruses. Acoziborole targets the trypanosome pre-mRNA processing endonuclease, cleavage and polyadenylation specificity factor 3 (CPSF3), and triggers...

Topics

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Drug Resistance
Mutation
Protozoan Proteins
Trypanocidal Agents
Trypanosoma brucei brucei

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trypanosomiasis, African

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Open in PubMed Open full text

Identifiers

PMID: 41774758
DOI: 10.1371/journal.ppat.1013764
PMCID: PMC12970967

Genes

CPSF3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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