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Article

A CRISPR-based diagnostic tool to survey drug resistance in human African trypanosomiasis.

Antimicrobial agents and chemotherapy - 10 Dec 2025

Pérez Antón Elena, Dujeancourt-Henry Annick, Rotureau Brice, Glover Lucy

Abstract excerpt

The World Health Organization aims to eliminate human African trypanosomiasis caused by Trypanosoma brucei gambiense (gHAT) by 2030. With the decline of reported cases, maintaining active surveillance is essential, including for the potential emergence of drug-resistant parasites. We have developed new highly specific diagnostic tools, using the Cas13a-based Specific High-Sensitivity Reporter Enzymatic UnLOCKing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41251373
DOI: 10.1128/aac.00933-25
PMCID: PMC12691586

Genes

CPSF3
AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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