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Mechanistic insights into the activity of Benzoxaboroles against <i>Cryptosporidium parvum</i> : CPSF3 targeting and resistance implications

2025-10-09

Abstract excerpt

Benzoxaboroles are emerging as promising treatments against a broad range of protozoan parasites, including Trypanosoma , Leishmania , Plasmodium , Toxoplasma , and Cryptosporidium . We previously demonstrated that the benzoxaborole compound AN3661 inhibits the endonuclease activity of CPSF3 in Cryptosporidium hominis , likely by disrupting pre-mRNA processing, which in turn limits parasite growth. In this s...

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Literature Corpus work
42384d09-0b5d-5053-8312-2af34998d759
DOI
10.1101/2025.10.09.681364
Open publication

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