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The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

25 Sept 2018

Abstract excerpt

Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potential novel anti-trypanosomal therapies, with candidates already in human and animal clinical trials. We investigated the mechanism of action of several benzoxaboroles,...

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PMID: 30252911
DOI: 10.1371/journal.ppat.1007315

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