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<i>In Silico</i> -Driven Engineering of <i>Halomonas elongata</i> L-Asparaginase: Towards Enhanced Proteolytic Resistance in Lymphoblastic Leukemia

2024-06-08

Abstract excerpt

The shortened L-asparaginase’s half-life in leukemia patients due to elevated serum proteases, poses a challenge. This study aimed to enhance the stability of Halomonas elongata L-asparaginase against trypsin. Employing the trRosetta server, we modeled the enzyme’s 3D structure with a quality score of 96.5, revealing predominant secondary structure of random coils (42%), alpha helices (33%), and extended strands...

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Literature Corpus work
31a4d3fd-5ed7-5084-9031-918eced8629f
DOI
10.1101/2024.06.07.597648
Open publication

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<i>In Silico</i> -Driven Engineering of <i>Halomonas elongata</i> L-Asparaginase: Towards Enhanced Proteolytic Resistance in Lymphoblastic LeukemiaDOI 10.1101/2024.06.07.597648
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