<scp>l</scp> -Asparaginase as a new molecular target against leishmaniasis: insights into the mechanism of action and structure-based inhibitor design

Abstract excerpt

l-Asparaginases belong to a family of amidohydrolases that catalyze the conversion of l-asparagine into l-aspartic acid and ammonia. Although bacterial l-asparaginases have been used extensively as anti-leukemic agents, their possible role as potential drug targets for pathogenic organisms has not been explored. The presence of genes coding for putative l-asparaginase enzymes in the Leishmania donovani genome...

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