Article

Molecular architecture and spatial organisation of proteasomes in the human sperm nucleus

2025-12-18

Abstract excerpt

Proteasomes are proteolytic machines essential for proteostasis and genome integrity. They consist of a 20S core particle capped by regulatory complexes that confer substrate selectivity (Voges, 1999). Despite evidence that proteasome function is necessary for successful spermatogenesis and fertilisation (Sutovsky, 2011; Xiong et al ., 2022), the presence, composition, and role of proteasomes within the sperm nuc...

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Literature Corpus work: 31a4d350-806f-5eb5-9909-8eac79857e46
DOI: 10.64898/2025.12.16.694293

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