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<i>In-cell</i> structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

2025-08-04

Abstract excerpt

In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nature, their architecture in native membranes has been hitherto elusive. Here, we combine in-situ electron cryo-tomography, AlphaFold predictions and molecular dynamics simulations to determine the sub-nanometer-resolu...

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Literature Corpus work
8c632d4b-ebef-500e-a2b0-2165d7e11dcd
DOI
10.1101/2025.08.04.668116
Open publication

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<i>In-cell</i> structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cellsDOI 10.1101/2025.08.04.668116
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