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Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-<sup>13</sup>C]Pyruvate MR Spectroscopy

2023-10-19

Abstract excerpt

<h4>Abstract Summary</h4> <h4>Introduction</h4> The normal heart has remarkable metabolic flexibility that permits rapid switching between mitochondrial glucose oxidation and fatty acid (FA) oxidation to generate ATP. Loss of metabolic flexibility has been implicated in the genesis of contractile dysfunction seen in cardiomyopathy. Metabolic flexibility has been imaged in experimental models, using hyperpolarized...

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Literature Corpus work
3193c8d1-1cf8-5f7a-bd6d-c7b6f6ae82d5
DOI
10.1101/2023.10.16.23297053
Open publication

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