Back to search

Article

Hyperpolarized 13C MRI uncovers early and progressive metabolic dysfunction in the hAPP-J20 mouse model of Alzheimer’s disease

2026-07-27

Abstract excerpt

<title>Abstract</title> <p> Impaired brain energy metabolism is an early feature of Alzheimer's disease (AD), but the standard metabolic imaging tool, [ <sup>18</sup> F]FDG-PET, reports only glucose uptake and cannot resolve downstream metabolic flux nor inform on overall metabolic profile of the brain. In this study, we used [ <sup>18</sup> F]FDG-PET, hyperpolarized (HP) [1- <sup>13</sup> C]pyruvate <sup...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d4717f7f-d71e-5aa7-8587-352b918883f7
DOI
10.21203/rs.3.rs-10437814/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Hyperpolarized 13C MRI uncovers early and progressive metabolic dysfunction in the hAPP-J20 mouse model of Alzheimer’s diseaseDOI 10.21203/rs.3.rs-10437814/v1
The Impact of the hAPP695 SW Transgene and Associated Amyloid-β Accumulation on Murine Hippocampal Biochemical PathwaysSemantic proximity
Longitudinal analysis of UK Biobank participants suggests age and APOE-dependent alterations of energy metabolism in development of dementiaSemantic proximity
Proteomic and metabolic profiling reveals <i>APOE4</i> -dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysisSemantic proximity
APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic GlycolysisSemantic proximity
Metabolic Coherence of the Mouse BrainSemantic proximity
Requirement for oxidation of neuronal ketone bodies in aging and neurodegenerationSemantic proximity
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease.Semantic proximity
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.Semantic proximity
NMR Analysis of the Correlation of Metabolic Changes in Blood and Cerebrospinal Fluid in Alzheimer Model Male and Female MiceSemantic proximity
Global metabolic reprogramming and sex-specific impact of caloric restriction in a mouse model of Alzheimer’s diseaseSemantic proximity
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease.Semantic proximity
Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-<sup>13</sup>C]Pyruvate MR SpectroscopySemantic proximity
Select a neighboring publication to make it the new centre.