Article
Metabolic phenotyping of the diseased rat heart using 13C-substrates and ex vivo perfusion in the working mode.
Molecular and cellular biochemistry - 1 Jan 2003
Vincent Geneviève, Khairallah Maya, Bouchard Bertrand, Des Rosiers Christine
Abstract excerpt
The objective of the present study was to compare energy substrate fluxes through metabolic pathways leading to mitochondrial citrate synthesis and release in normal and diseased rat hearts using 13C-substrates and mass isotopomer analysis by gas chromatography-mass spectrometry (GCMS). This study was prompted by our previous finding of a modulated citrate release by perfused rat hearts and by the possibility...
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