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Hyperpolarized 13C Magnetic Resonance Reveals Early- and Late-Onset Changes to <i>in vivo</i> Pyruvate Metabolism in the Failing Heart

20 Dec 2012

Abstract excerpt

AIMS: Impaired energy metabolism has been implicated in the pathogenesis of heart failure. Hyperpolarized (13)C magnetic resonance (MR), in which (13)C-labelled metabolites are followed using MR imaging (MRI) or spectroscopy (MRS), has enabled non-invasive assessment of pyruvate metabolism. We investigated the hypothesis that if we serially examined a model of heart failure using non-invasive hyperpolarized...

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PMID: 23258802
DOI: 10.1093/eurjhf/hfs192

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