Article
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles.
Science (New York, N.Y.) - 27 Jul 2001
Wittmann C W, Wszolek M F, Shulman J M, Salvaterra P M, Lewis J, Hutton M, Feany M B
Abstract excerpt
The microtubule-binding protein tau has been implicated in the pathogenesis of Alzheimer's disease and related disorders. However, the mechanisms underlying tau-mediated neurotoxicity remain unclear. We created a genetic model of tau-related neurodegenerative disease by expressing wild-type and mutant forms of human tau in the fruit fly Drosophila melanogaster. Transgenic flies showed key features of the human...
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