Article

Construction of a germline-specific RNAi tool in <i>C. elegans</i>

2018-10-18

Abstract excerpt

Analysis of complex biological functions usually requires tissue-specific genetic manipulations in multicellular organisms. The C. elegans germline plays regulatory roles not only in reproduction, but also in metabolism, stress response and aging. Previous studies have used mutants of rrf-1 , which encodes an RNA-directed RNA polymerase, as a germline-specific RNAi tool. However, the rrf-1 mutants showed RNAi e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 29c25087-0722-5d44-a908-5452bb2562ef
DOI: 10.1101/446898

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Construction of a germline-specific RNAi tool in <i>C. elegans</i>DOI 10.1101/446898Read

Validation of tissue-specific RNAi systems in <i>C. elegans</i> reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin metabolism and lifespanSemantic proximity Read

New strains for tissue-specific RNAi studies in <i>Caenorhabditis elegans</i>Semantic proximity Read

C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline.Semantic proximity Read

Diversification of small RNA pathways underlies germline RNAi incompetence in wild <i>C. elegans</i> strainsSemantic proximity Read

The RNAi Inheritance Machinery of Caenorhabditis elegans.Semantic proximity Read

CCAR-1 has a novel role in regulating the <i>Caenorhabditis elegans</i> germlineSemantic proximity Read

A cytoplasmic Argonaute protein promotes the inheritance of RNAiSemantic proximity Read

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environmentSemantic proximity Read

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.Semantic proximity Read

Somatic aging pathways regulate reproductive plasticity in <i>Caenorhabditis elegans</i>Semantic proximity Read

Identification of essential genes in <i>Caenorhabditis elegans</i> through whole genome sequencing of legacy mutant collectionsSemantic proximity Read

Genome-wide temporal gene expression reveals a post-reproductive shift in the nematode <i>C. briggsae</i>Semantic proximity Read