Article

Germ Granules Functions are Memorized by Transgenerationally Inherited Small RNAs

2019-03-14

Abstract excerpt

In C. elegans nematodes, components of liquid-like germ granules were shown to be required for transgenerational small RNA inheritance. Surprisingly, we show here that mutants with defective germ granules ( pptr-1 , meg-3/4 , pgl-1 ) can nevertheless inherit potent small RNA-based silencing responses, but some of the mutants lose this ability after many generations of homozygosity. Animals mutated in pptr-1 ,...

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Literature Corpus work: dffdcf1d-4528-5346-b6c9-0a4f49db52ba
DOI: 10.1101/576934

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