Article

Runx3 prevents spontaneous colitis by directing differentiation of anti-inflammatory mononuclear phagocytes

2019-08-21

Abstract excerpt

<h4>ABSTRACT</h4> RUNX3 is one of three mammalian Runt-domain transcription factors (TFs) that regulate gene expression in several types of immune cells. Runx3-deficiency in mice is associated with a multitude of defects in the adaptive and innate immunity systems, including the development of early onset colitis. Our study reveals that conditional deletion of Runx3 specifically in mononuclear phagocytes (MNP) (M...

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Literature Corpus work: 31603e6f-4576-5781-b21d-b75062380747
DOI: 10.1101/742650

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