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Transcription factor-driven regulation of ILC1 and ILC3

23 May 2022

Abstract excerpt

Mammalian innate lymphoid cells (ILCs) have functional relevance under both homeostatic and disease settings, such as inflammatory bowel disease (IBD), particularly in the context of maintaining the integrity of mucosal surfaces. Early reports highlighted group 1 and 3 ILC regulatory transcription factors (TFs), T-box expressed in T cells (T-bet; Tbx21) and RAR-related orphan nuclear receptor γt (RORγt; Rorc), as...

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PMID: 35618586
DOI: 10.1016/j.it.2022.04.009

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