Article

Structure of nucleotide-bound Tel1 <sup>ATM</sup> reveals the molecular basis of inhibition and structural rationale for disease mutations

2019-07-08

Abstract excerpt

<h4>SUMMARY</h4> Yeast Tel1 and its highly conserved human orthologue ATM are large protein kinases central to the maintenance of genome integrity. Mutations in ATM are found in ataxia-telangiectasia (A-T) patients and ATM is one of the most frequently mutated genes in many cancers. Using cryo electron microscopy, we present the structure of Tel1 in a nucleotide-bound state. Our structure reveals molecular detail...

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Literature Corpus work: 3159495f-219e-58a6-986e-e2c129b82c7e
DOI: 10.1101/696203

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