Article

Insights into mechanisms of ATM activation via constitutively active mutants

2026-07-15

Abstract excerpt

The Ser/Thr kinase ATM orchestrates cellular responses to DNA double-strand breaks (DSBs) and promotes DSB repair by homologous recombination. In this process, ATM is activated by DNA and the MRN (MRE11, RAD50, and NBS1) complex. Here we show that mutations of the conserved PIKK regulatory domain (PRD) within ATM’s kinase domain can confer a maximally active state that no longer requires MRN/DNA. In ATM-knockout h...

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Literature Corpus work: ac6f7d97-69e1-5348-9352-a5768cb9c66a
DOI: 10.64898/2026.07.15.738190

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