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Article

Structure of the human ATM kinase and mechanism of Nbs1 binding.

eLife - 25 Jan 2022

Warren Christopher, Pavletich Nikola P

Abstract excerpt

DNA double-strand breaks (DSBs) can lead to mutations, chromosomal rearrangements, genome instability, and cancer. Central to the sensing of DSBs is the ATM (Ataxia-telangiectasia mutated) kinase, which belongs to the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family. In response to DSBs, ATM is activated by the MRN (Mre11-Rad50-Nbs1) protein complex through a poorly understood process that also...

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Identifiers

PMID: 35076389
DOI: 10.7554/eLife.74218
PMCID: PMC8828054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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