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Article

Cryo-EM structure of human ATR-ATRIP complex.

Cell research - 1 Feb 2018

Rao Qinhui, Liu Mengjie, Tian Yuan, Wu Zihan, Hao Yuhan, Song Lei, Qin Zhaoyu, Ding Chen, Wang Hong-Wei, Wang Jiawei, Xu Yanhui

Abstract excerpt

ATR (ataxia telangiectasia-mutated and Rad3-related) protein kinase and ATRIP (ATR-interacting protein) form a complex and play a critical role in response to replication stress and DNA damage. Here, we determined the cryo-electron microscopy (EM) structure of the human ATR-ATRIP complex at 4.7 Å resolution and built an atomic model of the C-terminal catalytic core of ATR (residues 1 521-2 644) at 3.9 Å...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29271416
DOI: 10.1038/cr.2017.158
PMCID: PMC5799817

Genes

ATR
ATRIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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