Article

Structure of the human ATM kinase and mechanism of Nbs1 binding

2021-10-17

Abstract excerpt

DNA double-strand breaks (DSBs) can lead to mutations, chromosomal rearrangements, genome instability, and ultimately cancer. Central to the sensing of DSBs are ATM (Ataxia-telangiectasia mutated) kinase, which belongs to the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family, and the MRN (Mre11-Rad50-Nbs1) protein complex that activates ATM. How the MRN complex recruits and activates ATM kinase is...

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Literature Corpus work: 145b751d-1afe-5b06-aa93-30370e1e4484
DOI: 10.1101/2021.10.17.464701

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