Article
Molecular basis of human ATM kinase inhibition.
Nature structural & molecular biology - 1 Oct 2021
Stakyte K, Rotheneder M, Lammens K, Bartho J D, Grädler U, Fuchß T, Pehl U, Alt A, van de Logt E, Hopfner K P
Abstract excerpt
Human checkpoint kinase ataxia telangiectasia-mutated (ATM) plays a key role in initiation of the DNA damage response following DNA double-strand breaks. ATM inhibition is a promising approach in cancer therapy, but, so far, detailed insights into the binding modes of known ATM inhibitors have been hampered due to the lack of high-resolution ATM structures. Using cryo-EM, we have determined the structure of human...
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