Article

Microbiome contribution to <i>Indy</i> longevity in <i>Drosophila</i>

2026-03-26

Abstract excerpt

Reduction in the Indy (I’m not dead yet) gene, a plasma membrane citrate transporter, in Drosophila and its homolog in worms extends lifespan by promoting metabolic homeostasis. Indy reduction delays the onset of aging-associated pathology in the fly midgut, including preservation of intestinal barrier integrity and intestinal stem cell homeostasis. Gut microbiota has broad impacts on host metabolism, health, a...

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Identifiers and source

Literature Corpus work: 3133245f-5fbe-510a-b18f-2eed980f2bb6
DOI: 10.64898/2026.03.25.714291

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