Article

Comprehensive investigation of SARS-CoV-2 intestinal pathogenesis in <i>Drosophila</i>

2025-06-26

Abstract excerpt

Gastrointestinal (GI) manifestations have been increasingly reported in COVID-19 patients. Here, we use the Drosophila melanogaster midgut model to investigate SARS-CoV-2-induced GI pathogenesis. The fly midgut exhibits susceptibility to orally administered virus, resulting in disrupted epithelial architecture, reduced organ size, and altered visceral muscle dynamics. These effects are accompanied by sustained pr...

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Identifiers and source

Literature Corpus work: 121a544d-3ac9-53a2-9640-00bfd1316516
DOI: 10.1101/2025.06.25.661044

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