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Article

Host genetics and diet jointly shape the microbiome of Drosophila melanogaster but do not predict lifespan or age-related traits.

Biogerontology - 4 May 2026

Bak Nikolaj Klausholt, Østergaard Stine Karstenskov, Schacksen Patrick Skov, Nielsen Jeppe Lund, Rohde Palle Duun, Kristensen Torsten Nygaard

Abstract excerpt

The microbiome is a key determinant of organismal health, yet inter-individual variability and heterogeneous responses to environmental conditions complicates the understanding of its effects on hosts. Here, we present a comprehensive analysis using the Drosophila Genetic Reference Panel (DGRP) to investigate how the interplay between host genetic variation and diet influences microbiome composition, and to...

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PMID: 42081130
DOI: 10.1007/s10522-026-10431-2
PMCID: PMC13139259

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