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Article

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in <i>Drosophila</i>

12 Dec 2012

Abstract excerpt

Aging is characterized by a growing risk of disease and death, yet the underlying pathophysiology is poorly understood. Indeed, little is known about how the functional decline of individual organ systems relates to the integrative physiology of aging and probability of death of the organism. Here we show that intestinal barrier dysfunction is correlated with lifespan across a range of Drosophila genotypes and...

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PMID: 23236133
DOI: 10.1073/pnas.1215849110

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