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Article

The longevity gene INDY ( I 'm N ot D ead Y et) in metabolic control: Potential as pharmacological target

11 Oct 2017

Abstract excerpt

The regulation of metabolic processes by the Indy (I'm Not Dead Yet) (SLC13A5/NaCT) gene was revealed through studies in Drosophila melanogaster and Caenorhabditis elegans. Reducing the expression of Indy in these species extended their life span by a mechanism resembling caloric restriction, without reducing food intake. In D. melanogaster, mutating the Indy gene reduced body fat content, insulin-like proteins...

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PMID: 28987323
DOI: 10.1016/j.pharmthera.2017.10.003

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