Article

Parkinson's disease progression is shaped by longitudinal changes in cerebral compensation

2025-03-21

Abstract excerpt

Parkinson's disease (PD) is a common and debilitating neurodegenerative disorder characterized by motor slowing (bradykinesia), which is thought to arise mainly due to nigro-striatal dopaminergic cell loss. Paradoxically, longitudinal changes in striatal dopamine relate poorly to the progression of bradykinesia, indicating that other pathophysiological mechanisms play a role. In line with this, cross-sectional stu...

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Literature Corpus work: 311df38c-5b53-550e-bda5-e65e0de37fd9
DOI: 10.1101/2025.03.21.25324393

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