Article
Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype.
Neurology - 24 Mar 2009
van Nuenen B F L, Weiss M M, Bloem B R, Reetz K, van Eimeren T, Lohmann K, Hagenah J, Pramstaller P P, Binkofski F, Klein C, Siebner H R
Abstract excerpt
OBJECTIVE: To use a combined neurogenetic-neuroimaging approach to examine the functional consequences of preclinical dopaminergic nigrostriatal dysfunction in the human motor system. Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease alters the cortical control of sequential finger movements. METHODS: Nonmanifesting individuals...
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