Article

Transient dopamine neuron activity precedes and encodes the vigor of contralateral movements

2021-04-20

Abstract excerpt

Dopamine neurons (DANs) in the substantia nigra pars compacta (SNc) have been related to movement vigor, and loss of these neurons leads to bradykinesia in Parkinson’s disease. However, it remains unclear whether DANs encode a general motivation signal or modulate movement kinematics. We imaged activity of SNc DANs in mice trained in a novel operant task which relies on individual forelimb sequences. We uncovered...

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Literature Corpus work: 86c988f3-5a1b-51a0-acd1-02c2c05f3f3c
DOI: 10.1101/2021.04.20.440527

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