Article

Clinical severity in Parkinson’s disease is determined by decline in cortical compensation

2023-04-17

Abstract excerpt

Dopaminergic dysfunction in the basal ganglia, particularly in the post-commissural putamen, is often viewed as the primary pathological mechanism behind motor slowing (i.e., bradykinesia) in Parkinson’s disease. However, striatal dopamine loss fails to account for inter-individual differences in motor phenotype and rate of decline, implying that the expression of motor symptoms depends on additional mechanisms, s...

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Literature Corpus work: 2931741a-3bc7-5ca3-ac95-1dd9808c1103
DOI: 10.1101/2023.04.16.23288636

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