Article
Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.
EBioMedicine - 1 Oct 2015
Klöppel Stefan, Gregory Sarah, Scheller Elisa, Minkova Lora, Razi Adeel, Durr Alexandra, Roos Raymund A C, Leavitt Blair R, Papoutsi Marina, Landwehrmeyer G Bernhard, Reilmann Ralf, Borowsky Beth, Johnson Hans, Mills James A, Owen Gail, Stout Julie, Scahill Rachael I, Long Jeffrey D, Rees Geraint, Tabrizi Sarah J
Abstract excerpt
BACKGROUND: Cognitive and motor task performance in premanifest Huntington's disease (HD) gene-carriers is often within normal ranges prior to clinical diagnosis, despite loss of brain volume in regions involved in these tasks. This indicates ongoing compensation, with the brain maintaining function in the presence of neuronal loss. However, thus far, compensatory processes in HD have not been modeled explicitly....
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