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Acute levodopa reorganizes rather than normalizes the Parkinsonian brain: a multiscale connectomic, molecular, and transcriptomic analysis.

2026-06-24

Abstract excerpt

<title>Abstract</title> <p>Levodopa is the most effective symptomatic treatment for Parkinson's disease (PD), yet whether it returns the brain toward health or reorganizes it into a new state is unresolved. We traced the acute levodopa response across scales in 34 patients (resting-state functional MRI, OFF and ON) versus 36 matched controls, following it from local activity (amplitude of low-frequency fluctuatio...

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Literature Corpus work
26a791ca-c093-532e-ab93-60889a6fc7f4
DOI
10.21203/rs.3.rs-9959609/v1
Open publication

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Acute levodopa reorganizes rather than normalizes the Parkinsonian brain: a multiscale connectomic, molecular, and transcriptomic analysis.DOI 10.21203/rs.3.rs-9959609/v1
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