Article
Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism.
Brain : a journal of neurology - 1 Dec 2012
van Nuenen Bart F L, Helmich Rick C, Ferraye Murielle, Thaler Avner, Hendler Talma, Orr-Urtreger Avi, Mirelman Anat, Bressman Susan, Marder Karen S, Giladi Nir, van de Warrenburg Bart P C, Bloem Bastiaan R, Toni Ivan
Abstract excerpt
Compensatory cerebral mechanisms can delay motor symptom onset in Parkinson's disease. We aim to characterize these compensatory mechanisms and early disease-related changes by quantifying movement-related cerebral function in subjects at significantly increased risk of developing Parkinson's disease, namely carriers of a leucine-rich repeat kinase 2-G2019S mutation associated with dominantly inherited...
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