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Article

Mapping preclinical compensation in Parkinson's disease: an imaging genomics approach.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2009

van Nuenen Bart F L, van Eimeren Thilo, van der Vegt Joyce P M, Buhmann Carsten, Klein Christine, Bloem Bastiaan R, Siebner Hartwig R

Abstract excerpt

Mutations in the Parkin (PARK2) and PINK1 gene (PARK 6) can cause recessively inherited Parkinson's disease (PD). The presence of a single Parkin or PINK1 mutation is associated with a dopaminergic nigrostriatal dysfunction and conveys an increased risk to develop PD throughout lifetime. Therefore neuroimaging of non-manifesting individuals with a mutant Parkin or PINK1 allele opens up a window for the...

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Source

Identifiers

PMID: 19877238
DOI: 10.1002/mds.22635

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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