Article
Cerebral compensation during motor function in Friedreich ataxia: The IMAGE-FRDA study.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2017
Harding Ian H, Corben Louise A, Delatycki Martin B, Stagnitti Monique R, Storey Elsdon, Egan Gary F, Georgiou-Karistianis Nellie
Abstract excerpt
BACKGROUND: Friedreich ataxia is characterized by progressive motor incoordination that is linked to peripheral, spinal, and cerebellar neuropathology. Cerebral abnormalities are also reported in Friedreich ataxia, but their role in disease expression remains unclear. METHODS: In this cross-sectional functional magnetic resonance imaging study, 25 individuals with Friedreich ataxia and 33 healthy controls...
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