Article

Membrane positioning across antigen-induced synaptic contacts tunes CAR-T cell signaling and effector responses

2023-10-02

Abstract excerpt

Tumor antigen recognition by chimeric antigen receptors (CAR) triggers phosphorylation of their cytoplasmic portions resulting in CAR-T cell activation. We and others have shown that immunoreceptor triggering depends on the formation of close synaptic contacts, determined by the span of immunoreceptor-ligand complexes, from which large inhibitory phosphatases such as CD45 are sterically excluded. Here, we show, va...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e67e3c0e-8593-55b5-a6ac-90cf10dc0fcf
DOI: 10.1101/2023.10.01.560371

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Membrane positioning across antigen-induced synaptic contacts tunes CAR-T cell signaling and effector responsesDOI 10.1101/2023.10.01.560371Read

Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs)Semantic proximity Read

Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexesSemantic proximity Read

T Cell Activation Machinery: Form and Function in Natural and Engineered Immune ReceptorsSemantic proximity Read

Chimeric antigen receptor signaling: Functional consequences and design implicationsSemantic proximity Read

Fine-tuning the CAR spacer improves T-cell potencySemantic proximity Read

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell functionSemantic proximity Read

Dissecting the role of CAR signaling architectures on T cell activation and persistence using pooled screens and single-cell sequencingSemantic proximity Read

Adoptive cell therapy using T cell receptors equipped with ICOS yields durable anti-tumor responseSemantic proximity Read

CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sitesSemantic proximity Read

Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerationsSemantic proximity Read

CAR macrophages with built-In CD47 blocker combat tumor antigen heterogeneity and activate T cells via cross-presentationSemantic proximity Read

Chimeric antigen receptors that trigger phagocytosisSemantic proximity Read