Article
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.
Immunity - 1 Mar 2001
Bunnell S C, Kapoor V, Trible R P, Zhang W, Samelson L E
Abstract excerpt
T cell activation induces functional changes in cell shape and cytoskeletal architecture. To facilitate the collection of dynamic, high-resolution images of activated T cells, we plated T cells on coverslips coated with antibodies to the T cell receptor (TCR). Using these images, we were able to quantitate the morphological responses of individual cells over time. Here, we show that TCR engagement triggers the...
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