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Article

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis.

Nature communications - 14 Jan 2020

Schafflick David, Xu Chenling A, Hartlehnert Maike, Cole Michael, Schulte-Mecklenbeck Andreas, Lautwein Tobias, Wolbert Jolien, Heming Michael, Meuth Sven G, Kuhlmann Tanja, Gross Catharina C, Wiendl Heinz, Yosef Nir, Meyer Zu Horste Gerd

Abstract excerpt

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains superficial. Here, using single cell transcriptomics, we identify a specific location-associated composition and transcriptome of CSF leukocytes. Multiple sclerosis (MS) - an autoimmune disease of the CNS - increases transcriptional diversity in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Encephalomyelitis, Autoimmune, Experimental

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Source

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Identifiers

PMID: 31937773
DOI: 10.1038/s41467-019-14118-w
PMCID: PMC6959356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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