Article

An EBV-associated atypical B cell signature in clinically isolated syndrome is implicated in progression of multiple sclerosis

2023-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Expansion and pathogenicity of CD19 + /CD20 + /CD11c + /T-bet + atypical B cells (ABCs) are hallmarks of numerous autoimmune disorders and chronic infections. In many such cases Epstein-Barr virus (EBV) is another associated or etiologic factor, though EBV involvement in these diseases remains poorly understood. Notably, the expansion of pro-inflammatory ABCs and a putative causal role for EBV ha...

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Literature Corpus work: 04df69b4-9bf3-505b-b849-116036ade0b8
DOI: 10.1101/2023.02.26.23286433

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