Article
Early multiple sclerosis activity associated with TBX21+CD21loCXCR3+ B cell expansion resembling EBV-induced phenotypes.
JCI insight - 23 Jun 2025
SoRelle Elliott D, Haukenfrers Ellora, Horn Gillian Q, Jain Vaibhav, Giarraputo James, Abramson Karen, Hocke Emily, Cooney Laura A, Harris Kristina M, Zamvil Scott S, Gregory Simon G, Luftig Micah A
Abstract excerpt
Epstein-Barr virus (EBV) infection precedes multiple sclerosis (MS) onset and plays a poorly understood etiologic role. To investigate possible viral pathogenesis, we analyzed single-cell expression in peripheral B cells from people with early MS collected longitudinally during the Immune Tolerance Network STAyCIS Trial. Expression profiles were compared with single-cell RNA-Seq (scRNA-Seq) from in vitro EBV...
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