Article
The pan-cancer mutational landscape of MLL3 and its impact on prognosis and immunochemotherapy.
Cell reports - 25 Nov 2025
Liu Xinhua, Xu Yang, Wang Yue, Jiang Li, Yu Chunyu, Wang Ying, Wang Jianqiu, Yao Qianqian, Tang Zifan, Zhang Chengying, Shang Yongfeng
Abstract excerpt
Although recurrent mutations of MLL3 are reported in various cancers, and MLL3 represents one of the most commonly mutated cancer genes, a pan-cancer-wide portrait of this high-frequency mutational event is still lacking. Here, we report that the genetic alterations in MLL3 in 33 cancer types are primarily driven by point mutations or small insertions and deletions (indels) and exhibit lineage-specific...
Read the complete abstract on PubMedTopics
- Humans
- Animals
- Mutation
- Neoplasms
- Mice
- Prognosis
- Immunotherapy