Article
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells.
Immunity - 12 Aug 2025
Boutet Marie, Nishitani Kenta, Couturier Nicole, Erler Piril, Zhang Zheng, Militello Anna Maria, Coutinho De Miranda Marcelo, Barbieux Emeline, Guillen Erik, Leavenworth Jianmei W, Suzuki Masako, Sparano Joseph A, Lu Jinyu, Fineberg Susan A, Wang Yihong, Mani Sendurai A, Montagna Cristina, Guo Wenjun, Lauvau Gregoire
Abstract excerpt
Loss-of-function mutations in MLL3, encoding the histone methyltransferase MLL3/KMT2C, are frequent in various cancer types. To examine the mechanisms whereby MLL3 suppresses tumorigenesis, we developed a mouse mammary-stem-cell-based tumor model bearing cancer-driver mutations, including loss of MLL3/KMT2C and p53 and constitutive phosphatidylinositol 3-kinase (PI3K) activation, recapitulating a genetic makeup...
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