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Pancancer Fine-Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 May 2026

Wang Tao, Zhao Hongyu, Sun Xiaojie, Ding Yuqi, Zhu Zhipeng, Yu Xiaotong, Zhu Rongyi, Wang Dan, Li Kailong, Liu Yang, Wang Li-Bin, Zhao Xiaolu, Suo Baojun, Bi Hongsen, Zhang Peipei, Liu Tong, Mao Fengbiao

Abstract excerpt

Mutation-intolerant genes (MIGs), which are constrained in tumors yet variable in normal tissues, are critical for cancer survival. Herein, we developed miDriver, a computational framework using pancancer-normal mutation contrasts to identify 1,020 MIGs across 8,096 tumors of 13 cancer types. Strikingly, MIGs are highly associated with synthetic lethality, cell-cycle progression, and clinical outcome. CRISPR...

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Share to Adenocarcinoma of Lung
Share to Antigens, Differentiation, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Checkpoint Kinase 1

Share to Histocompatibility Antigens Class II

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Source

Open in PubMed Open full text

Identifiers

PMID: 41722056
DOI: 10.1002/advs.202521265
PMCID: PMC13137788

Genes

CHEK1
MIF
CD74

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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