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Article

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

29 Oct 2018

Abstract excerpt

SRPK2 is abnormally activated in tauopathies including Alzheimer's disease (AD). SRPK2 is known to play an important role in pre-mRNA splicing by phosphorylating SR-splicing factors. Dysregulation of tau exon 10 pre-mRNA splicing causes pathological imbalances in 3R- and 4R-tau, leading to neurodegeneration; however, the role of SRPK2 in these processes remains unclear. Here we show that delta-secretase (also...

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PMID: 30373880
DOI: 10.1084/jem.20180539

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