Association between specific human leukocyte antigen alleles and development of thyroid immune-related adverse event.

doi:10.1080/1750743X.2024.2353539

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Article

Association between specific human leukocyte antigen alleles and development of thyroid immune-related adverse event.

Immunotherapy - 1 Jan 2024

Sasaki Eisaku, Natori Yutaka, Tokuda Emi, Kimura-Tsuchiya Reiko, Suga Junko, Kanazawa Kenya, Koguchi Tomoyuki, Kikuchi Nobuyuki, Okabe Naoyuki, Murono Shigeyuki, Tachibana Kazunoshin, Soeda Shu, Shimabukuro Michio, Saji Shigehira

Abstract excerpt

Aim: Inherent variations in human leukocyte antigen (HLA) alleles have been revealed epidemiologically to influence the development of autoimmune diseases. HLA alleles may thus also be associated with the development of immune-related adverse events (irAEs), such as thyroid irAE.Materials & methods: In this case-control study, 71 cancer patients who received immune checkpoint inhibitors were enrolled and...

Topics

Humans
Alleles
Male
Female
Case-Control Studies
Middle Aged
Neoplasms
Aged
Immune Checkpoint Inhibitors
Adult
Thyroid Gland

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA Antigens

Genotype

HLA-DP alpha-Chains

HLA-DP beta-Chains

Genetic Predisposition to Disease

Gene Frequency

Source

Open in PubMed Open full text

Identifiers

PMID: 38889451
DOI: 10.1080/1750743X.2024.2353539
PMCID: PMC11421297

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